BQCIS

Defining the Shelf Life and Storage Conditions of Your Product

Stability testing verifies that a product maintains efficacy, safety, and quality throughout its labeled shelf life under defined storage conditions. It is a core requirement for all regulatory submissions and market approvals.

Our cGMP-validated stability chambers operate under precise temperature and humidity controls aligned with ICH Q1A (R2). We conduct accelerated, intermediate, and long-term programs to define real-time shelf life and validate expiry labeling.

BQCIS partners with formulation and regulatory teams to design study protocols, manage pull points, and perform analytical testing—assay, dissolution, degradation, and impurity monitoring—producing defensible data packages for global submission.

Key Stability Program Services

ICH-Compliant Study Design & Storage

Tailored protocols covering climatic zones II–IV with long-term (real-time), intermediate, and accelerated conditions (e.g., 25°C/60% RH, 30°C/65% RH, 40°C/75% RH). Chambers are fully mapped, power-backed, and continuously monitored, ensuring sample integrity and reliable shelf-life data.

Forced Degradation & Photo-stability Studies

Forced degradation identifies degradation pathways via heat, humidity, hydrolysis, and oxidation stress testing. Photo-stability testing (ICH Q1B) determines the need for light protection. Data supports validation of stability-indicating analytical methods and packaging design.

Key Benefits of Stability Studies

Shelf Life

Define Reliable Shelf Life

Predicts and verifies product longevity under ICH-defined conditions, ensuring accurate expiry dating.

Compliance

Ensure Global Regulatory Compliance

Programs designed to meet FDA, EMA, and WHO expectations, facilitating international registration.

Quality

Maintain Product Quality

Continuous monitoring detects early degradation or impurity trends, protecting therapeutic efficacy.

Efficiency

Accelerate Time-to-Market

Accelerated and predictive data supports early submission and rapid approval, reducing development timelines.

Success Story

Accelerated Stability Data Supports Early Market Launch

The Challenge:

A biotech client required rapid stability evidence to support early regulatory submission for a biologic drug candidate.

Our Solution:

BQCIS executed an accelerated stability study under 40°C/75% RH, applying high-sensitivity analysis to track potency, degradation, and physical changes, aligned with ICH Q1A (R2).

The Result:

Within six months, data validated a 24-month provisional shelf life. The early report enabled expedited market authorization—six months ahead of schedule—securing a key competitive advantage.

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