BQCIS

Ensuring Product Safety, Efficacy, and Consistency

Analytical Chemistry forms the scientific foundation of product quality assurance in pharmaceuticals and medical devices. It ensures the chemical integrity, potency, and safety of all products — from API synthesis to final dosage form — in accordance with global GMP and ICH standards.

Our GMP/GLP-compliant laboratories utilize advanced HPLC, GC-MS, LC-MS/MS, NMR, FTIR, and UV-Vis platforms to provide quantitative and qualitative data for product release and regulatory submission. Each method is developed and validated to deliver precise, reproducible, and traceable results.

BQCIS supports clients from method development and impurity profiling to forced degradation and stability testing — providing the scientific evidence needed to meet global regulatory expectations and accelerate product-to-market timelines.

Key Analytical Services

Impurity and Degradation Product Profiling

Identification and quantification of impurities using HPLC-UV, GC-MS, LC-MS/MS, and HRMS to ensure product purity and compliance with FDA, EMA, and ICH Q3A/B guidelines. This profiling supports stability studies and batch release, providing full structural elucidation of unknowns through advanced mass spectrometric and NMR analysis.

Assay and Content Uniformity Testing

Precise determination of API potency and dosage consistency using validated analytical methods. These tests confirm uniform distribution of the active ingredient across tablets or capsules and verify potency within defined monograph limits — ensuring therapeutic efficacy and regulatory acceptance.

Key Benefits of Analytical Chemistry

Data Integrity

Ensure Data Integrity & Traceability

All analyses are conducted under ALCOA+ principles — ensuring that results are attributable, legible, contemporaneous, and audit-ready.

Regulatory

Support Global Regulatory Submissions

Provides scientifically defensible data packages for FDA, EMA, and WHO submissions, accelerating product registration.

Quality

Strengthen Product Quality & Consistency

Verifies chemical uniformity and stability, minimizing batch variability and ensuring consistent therapeutic performance.

Efficiency

Accelerate Development Timelines

Optimized methods shorten turnaround time for characterization and validation — expediting clinical and commercial release.

Success Story

Structural Elucidation Resolves API Impurity Crisis

The Challenge:

A pharmaceutical client identified an unexpected impurity spike during routine stability testing, halting release of a key API batch.

Our Solution:

BQCIS developed a rapid analytical workflow using HRMS and NMR to isolate and elucidate the impurity structure. The compound was traced to a solvent degradation pathway, verified through comparative reference standard testing.

The Result:

The client successfully adjusted their process, completed regulatory justification, and resumed production within one week — avoiding costly recall and maintaining uninterrupted global supply.

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